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HIV treatment matrix

This starter matrix lists common FDA-approved HIV medicines and fixed-dose combinations. It is intended as a readable reference, not prescribing guidance.

Treatment choices depend on viral load, resistance history, kidney/liver health, pregnancy, drug interactions, other conditions and patient preference.

Individual medicines by class

Class	Generic name	Brand name	Notes
NRTI	Abacavir	Ziagen	Often abbreviated ABC.
NRTI	Emtricitabine	Emtriva	Often abbreviated FTC.
NRTI	Lamivudine	Epivir	Often abbreviated 3TC.
NRTI	Tenofovir disoproxil fumarate	Viread	Often abbreviated TDF.
NRTI	Tenofovir alafenamide	Vemlidy	Often abbreviated TAF.
NNRTI	Doravirine	Pifeltro	Often abbreviated DOR.
NNRTI	Efavirenz	Sustiva	Often abbreviated EFV.
NNRTI	Etravirine	Intelence	Often abbreviated ETR.
NNRTI	Nevirapine	Viramune	Often abbreviated NVP.
NNRTI	Rilpivirine	Edurant	Often abbreviated RPV.
INSTI	Bictegravir	Part of Biktarvy	Often abbreviated BIC.
INSTI	Cabotegravir	Vocabria / Apretude	Oral and long-acting injectable uses differ.
INSTI	Dolutegravir	Tivicay	Often abbreviated DTG.
INSTI	Elvitegravir	Part of Stribild/Genvoya	Used in fixed-dose combinations.
INSTI	Raltegravir	Isentress	Often abbreviated RAL.
Protease inhibitor	Atazanavir	Reyataz	Often abbreviated ATV.
Protease inhibitor	Darunavir	Prezista	Often abbreviated DRV.
Protease inhibitor	Lopinavir/ritonavir	Kaletra	Combination PI booster product.
Protease inhibitor	Ritonavir	Norvir	Often used as a booster.
Entry/fusion/attachment	Enfuvirtide	Fuzeon	Fusion inhibitor.
Entry/fusion/attachment	Fostemsavir	Rukobia	Attachment inhibitor.
CCR5 antagonist	Maraviroc	Selzentry	Requires tropism testing.
Capsid inhibitor	Lenacapavir	Sunlenca	Long-acting capsid inhibitor.
Pharmacokinetic enhancer	Cobicistat	Tybost	Booster, not active against HIV alone.

Common fixed-dose combinations

Brand name	Generic components	Notes
Biktarvy	bictegravir / emtricitabine / tenofovir alafenamide	Single-tablet regimen.
Dovato	dolutegravir / lamivudine	Two-drug single-tablet regimen for selected patients.
Triumeq	abacavir / dolutegravir / lamivudine	Requires consideration of abacavir suitability.
Delstrigo	doravirine / lamivudine / tenofovir disoproxil fumarate	Single-tablet regimen.
Genvoya	elvitegravir / cobicistat / emtricitabine / tenofovir alafenamide	Boosted INSTI regimen.
Stribild	elvitegravir / cobicistat / emtricitabine / tenofovir disoproxil fumarate	Boosted INSTI regimen.
Symtuza	darunavir / cobicistat / emtricitabine / tenofovir alafenamide	Boosted PI single-tablet regimen.
Odefsey	emtricitabine / rilpivirine / tenofovir alafenamide	Rilpivirine-based single-tablet regimen.
Juluca	dolutegravir / rilpivirine	Two-drug maintenance regimen.
Cabenuva	cabotegravir / rilpivirine	Long-acting injectable regimen.
Descovy	emtricitabine / tenofovir alafenamide	Used in treatment combinations and PrEP in selected groups.
Truvada	emtricitabine / tenofovir disoproxil fumarate	Used in treatment combinations and PrEP.
Epzicom/Kivexa	abacavir / lamivudine	Brand varies by country.